Thursday
Mar312016

Avoiding Sun as Dangerous as Smoking

Via Medscape Medical News, Marcia Frellick

March 23, 2016

 

 

Nonsmokers who stayed out of the sun had a life expectancy similar to smokers who soaked up the most rays, according to researchers who studied nearly 30,000 Swedish women over 20 years.

This indicates that avoiding the sun "is a risk factor for death of a similar magnitude as smoking," write the authors of the article, published March 21 in the Journal of Internal Medicine. Compared with those with the highest sun exposure, life expectancy for those who avoided sun dropped by 0.6 to 2.1 years.

Pelle Lindqvist, MD, of Karolinska University Hospital in Huddinge, Sweden, and colleagues found that women who seek out the sun were generally at lower risk for cardiovascular disease (CVD) and noncancer/non-CVD diseases such as diabetes, multiple sclerosis, and pulmonary diseases, than those who avoided sun exposure.

And one of the strengths of the study was that results were dose-specific — sunshine benefits went up with amount of exposure.

The researchers acknowledge that longer life expectancy for sunbathers seems paradoxical to the common thinking that sun exposure increases risk for skin cancer.

"We did find an increased risk of...skin cancer. However, the skin cancers that occurred in those exposing themselves to the sun had better prognosis," Dr Lindqvist said.

Some Daily Exposure Important for Health

Given these findings, he told Medscape Medical News, women should not overexpose themselves to sun, but underexposure may be even more dangerous than people think.

"We know in our population, there are three big lifestyle factors [that endanger health]: smoking, being overweight, and inactivity," he said. "Now we know there is a fourth — avoiding sun exposure."

Sweden's restrictive guidance against sun exposure over the past 4 decades may be particularly ill-advised, the study finds, in a country where the maximum UV index is low (< 3) for up to 9 months out of the year.

Use of sunscreen is also widely misunderstood in the country and elsewhere, Dr Lindqvist said.

"If you're using it to be out longer in the sun, you're using it in the wrong manner," he said. However, "If you are stuck on a boat and have to be out, it's probably better to have sunscreen than not to have it."

Women with more pigmentation would be particularly well-served to stop avoiding sunshine, he said, adding that many people in India, for instance, follow guidelines like those in Sweden to avoid sun year round.

And because melanomas are rare among women with darker skin, benefit goes up in those populations when weighing sun exposure's risk against benefits, Dr Lindqvist said.

Age and Smoking Habits

The researchers studied sun exposure as a risk factor for all-cause mortality for 29,518 women with no history of malignancy in a prospective 20-year follow-up of the Melanoma in Southern Sweden cohort.

The women were recruited from 1990 to 1992 when they were 25 to 64 years old. Detailed information was available at baseline on sun-exposure habits and potential confounders such as marital status, education level, smoking, alcohol consumption, and number of births.

When smoking was factored in, even smokers at approximately 60 years of age with the most active sun-exposure habits had a 2-year longer life expectancy during the study period compared with smokers who avoided sun exposure, the researchers note.

The authors do, however, acknowledge some major limitations. Among them, it was impossible to differentiate between active sun-exposure habits and a healthy lifestyle, and they did not have access to exercise data.


 

Role of Vitamin D Still in Question

The results add to the longstanding debate on the role of vitamin D in health and the amount of it people need, but this study doesn't resolve the question.

"Whether the positive effect of sun exposure demonstrated in this observational study is mediated by vitamin D, another mechanism related to ultraviolet radiation, or by unmeasured bias cannot be determined. Therefore, additional research is warranted," the authors write.

"From Irish studies we know that vitamin D deficiency makes melanomas more malignant," Dr Lindqvist said.

"This is in agreement with our results; melanomas of [those not exposed] to the sun had a worse prognosis."

This study was supported by the Clintec at the Karolinska Institute; ALF (Faculty of Medicine, Lund University, Region Skane); the Swedish Cancer Society; and the Swedish Medical Research Council. Funding was also received from Lund University Hospital; the Gustav V Jubilee Fund; the Gunnar Nilsson Foundation; the Kamprad Foundation; and the European Research Council. The authors declared no relevant financial relationships.

J Intern Med. Published online March 16, 2016. 

 

 

We offer gut microbiome exchange (transplantation) as novel opportunity for lifespan extension, prevention and treatment of various and so far difficult to treat ailments (auto-immune diseases, multiple sclerosis, vision loss due to uveitis, metabolic disorders, neuro-psychiatric diseases, Parkinson and addictions, cardiovascular disease, endocrine disorders and low fertility, cancer).

 

PD Dr. med. Rainer Arendt
FMH Cardiology, Internal Medicine
Regenerative Medicine 

SWISS  PREVENTION  CLINIC
Klausstrasse 10
CH-8008 ZURICH
T +41 43 336 7260
M +41 78 825 0803
F +41 43 336 7261

rainer.arendt@swisspreventionclinic.ch

www.swisspreventionclinic.ch
www.patientcircle.org

Wednesday
Mar092016

NOVEL TREATMENT FOR LOW FERTILITY AND PRETERM  BIRTH

Breaking news in fertility research, infant and reproductive health:
Semin Fetal Neonatal Med. 2016 Feb 26. pii: S1744-165X(16)00020-2. doi: 10.1016/j.siny.2016.02.004. [Epub ahead of print]



Maternal microbiome



Despite great medical advances in preventing maternal and infant mortality in the past century, one issue remains unresolved: why do so many women give birth prematurely? A major new field of human microbiome studies has begun to shed light on the impact of microbes (of both the commensal and pathogen varieties) on pregnancy outcomes. Recent advances in next-generation sequencing and metagenomic analysis have revealed that maternal microbiomes at a variety of niches including the oral, vaginal, gut, cervical, and even the placenta itself govern pregnancy outcomes. In this review, we describe how alterations in the microbial biomasses impact preterm birth and we discuss the major research questions concerning the cause and/or interdependent relationships between microbiome, infection, and preterm delivery.



 

We offer gut microbiome exchange (transplantation) as novel opportunity for lifespan extension, prevention and treatment of various and so far difficult to treat ailments (auto-immune diseases, multiple sclerosis, vision loss due to uveitis, metabolic disorders, neuro-psychiatric diseases, Parkinson and addictions, cardiovascular disease, endocrine disorders and low fertility, cancer).

 

PD Dr. med. Rainer Arendt
FMH Cardiology, Internal Medicine
Regenerative Medicine 

SWISS  PREVENTION  CLINIC
Klausstrasse 10
CH-8008 ZURICH
T +41 43 336 7260
M +41 78 825 0803
F +41 43 336 7261

rainer.arendt@swisspreventionclinic.ch

www.swisspreventionclinic.ch
www.patientcircle.org

Tuesday
Jan122016

GOOD HEALTH, REJUVENATION AND LIFESPAN EXTENSION IN  SWITZERLAND

Novel Program 2016

 

PD Dr. med. Rainer Arendt
FMH Cardiology, Internal Medicine
Regenerative Medicine 

SWISS  PREVENTION  CLINIC
Klausstrasse 10
CH-8008 ZURICH
T +41 43 336 7260
M +41 78 825 0803
F +41 43 336 7261

rainer.arendt@swisspreventionclinic.ch

www.swisspreventionclinic.ch
www.patientcircle.org

The Dolder Grand Health & Aesthetic Link 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

LIFESPAN  EXTENSION

 

  • Already today it is possible to increase the telomere length of the chromosomes, translating into an extension of human lifespan by approximately 10 years, by prudent eating, regular exercise, stress relief, regular chelation/detox treatment and especially by epigenetic rejuvenation, i.e. the gut, skin and vaginal microbiome exchange (the Élie Metchnikoff cure), with additional benefits for wellbeing, performance, fertility, increased vitality, and prevention of disease / neurodegeneration / hormonal involution (degeneration) later in life.
  • Recent scientific successes in rejuvenation, extending the lifespan, and discovery of a variety of species (including humans of advanced ages) having negligible senescence (decay due to old age), allow us to cancel accelerated or premature ageing for younger humans, reverse ageing or at least significantly delay it for older humans.
  • Our aim is to extend the lifespan in good health and full vitality

 

EPIGENETICS  AND  MICROBIOME

 

  • Epigenetics is the study, in the field of genetics, of cellular and physiological phenotypic trait variations, caused by external or environmental factors, mainly by the biofilms on our skin, in our mouth, in our lungs, in our gut, in our vagina, placenta and sexual organs,  that switch genes on and off and affect how cells read genes
  • The microbiota or microbiome is the community of commensal, symbiotic microbes that share our body space, or in a stricter sense stick to external or internal body surfaces as a biofilm
  • The microbiome and the human host emerged as a unity along evolution by a process of integration
  • The human microbiome has a significant impact on human development (before birth via the biofilm on the placenta), health and well-being
  • It is the rich array of beneficial microbes in our intestines and in our biofilms that makes us the human beings we are, preserves our health, and determines our lifespan.

 

 

MICROBIOME AND BIOFILMS

 

  • The importance of the commensal microbiota that colonizes the skin, gut, vaginal, placental, and mucosal surfaces of the human body is being increasingly recognized through a rapidly expanding body of science studying the human microbiome
  • The human body consists of more than 90% of microbial cells. The gastrointestinal tract harbors trillions of beneficial microorganisms that influence the development and homeostasis of the host. Alterations in composition and function of the microbiota have been implicated in a multitude of metabolic and inflammatory diseases in humans
  • There is a burgeoning scientific field on the role of the human microbiome in ageing, age-related diseases, diabetes, obesity, atherosclerotic diseases,  allergic diseases, autoimmune diseases, neuropsychiatric illnesses, infections, inflammatory bowel disease, and cancer

 

Mayo Clin Proc. 2014;89(1):107-114

Current Opinion in Immunology 2014, 30:54–62

Best Practice & Research Clinical Gastroenterology 27 (2013) 127–137

 

MEASUREMENT OF LIFESPAN

 

  • The chromosomes contain almost all of a cell’s genes. The tips of every chromosome are called the telomeres, they protect the chromosome from damage
  • Each time a cell divides, a little bit of the telomere is lost (therefore, the telomeres are regarded as our biological clock). When the telomeres become very short, the cell can no longer divide and dies
  • Genetic and epigenetic factors, the interaction of the immune and hormonal systems with our microbiota, influence how quickly the telomeres shorten
  • Restauration of the youthful diversity of the human  microbiota, healthy eating styles, increased fitness, stress relief result in longer telomeres reflecting/causing extensions of our lifespan
  • We measure the length of the telomeres in a blood sample as a parameter of lifespan before and after treatment

 

 

 

GENIUS LOCI

Switzerland –the prime destination for health, vitality, rejuvenation and long life 

Since the early 18th century, Switzerland - along with Italy – began to be perceived by the contemporaries as the most beautiful landscapes in Europe. Ever since, it has been regarded a fountain of health, long before the first patients with tuberculosis were sent for the famous sun, air and mountain cures in the early 20th century.  

 

And especially today, Switzerland is a  frontrunner in medical technology, with a healthcare system rightfully acknowledged to be one of the best in the world, with its exceptional quality of care and the excellence of its medical facilities.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

University Hospital, main buildings of the University and the ETH, and the city of Zurich, Switzerland 

 

GOALS OF REGENERATIVE MEDICINE

 

  • Ruling out treatable disease (by a comprehensive checkup examination, imaging, endoscopy, laboratory medicine)
  • Treating treatable disease, alleviating non-treatable disease (based on academic medicine and amended by the newest treatments from cellular, biological medicine, nutrition sciences, sports physiology, lifestyle medicine and neurosciences)
  • Extending the lifespan by restauration of the youthful diversity of our biofilms nIncreasing one’s resources and living well: staying quick-witted, social and sexual
  • Sidestepping risk factors for disease (preventive medicine, cardio-vascular prevention, lifestyle changes, exchanging non-beneficial microbes, neuroprotection)
  • Improving neurofunction, cardiac function by restauration of the gut-brain axis, of the gut-heart axis
  • Restauration of the senescent immune system, prevention of cancer
  • Regeneration of our endocrine (hormonal) systems

 

TYPICAL INDICATIONS FOR REGENERATIVE MEDICINE

 

  • Prevention or treatment of accelerated arteriosclerosis of carotid or coronary arteries (stroke, heart attack or sudden cardiac death)
  • Prevention or treatment of metabolic disease, type 2 diabetes, obesity
  • Prevention or treatment of autoimmune disease (multiple sclerosis, rheumatoid arthritis, thyroiditis, type 1 diabetes, psoriasis, auto-immune hepatitis)
  • Prevention or treatment of neuro-degenerative disease (dementia, Alzheimer, Parkinson, depression, autism, rare and devastating neurological disease)
  • Prevention or treatment of eating disorders (anorexia nervosa, binge eating, bulimia nervosa)
  • Prevention or treatment of inflammatory diseases (colitis, allergies, eczema, chronic lung disease)
  • Rehabilitation following cancer treatment, restauration of the immune system
  • Infertility, improvement of reproductive health, prevention of pregnancy complications
  • Early menopause, hormonal involution, loss of libido, painful sexual intercourse, erectile dysfunction
  • Lifespan extension, improvement in vitality, male performance, female wellbeing

 

 

 

CASE REPORTS IN REGENERATIVE MEDICINE

 

  • A 46 years old successful entrepreneur from Russia’s pacific coast, with alcohol dependency and depression, his fiancée requested him to undergo treatment before marriage. Following six gut microbiome transfers from a completely alcohol- and drug-free merry donor, he has been clear of alcohol for one year, and was able to resume “social” drinking of one to two glasses of wine only for dinner during his 2nd “sober year”. His mood is stable, work and social performance is no longer endangered.  By now the wedding has taken place and the marriage is harmonious.
  • A 61 years old housewife and society lady from Kazan with diffuse hair loss that is unresponsive to medical therapy, undergoes three microbiome exchange treatments, she is pleased with fuller hair and smoother skin six months later, therefore, doesn’t avoid public events anymore, and resumes her roles in beneficence.
  • A gifted 18 years young Australian student with polycystic ovary syndrome, menstrual abnormality, weight gain, acne, virilisation and severe reactive depression with indigestion and obstipation, undergoes three gut microbiome exchange treatments and is started on a combination oral contraceptive. She loses 12kg within 12 months, her skin clears, and virilisation is reversed, bowel movements normalised, she has become again a popular and outgoing young lady.
  • A 43 years old Chinese entrepreneur with premature menopause undergoes three gut and vaginal microbiome exchange treatments, her menstrual cycle has resumed and is regular three months later. There are no more hot flushes. Sexual intercourse is no more painful.
  • A 62 years old politician from Indonesia presents for general rejuvenation treatment, two months after three microbiome exchange treatments, his friends notice a “miraculously” improved golf swing that is now “silky smooth”. His exercise tolerance and oxygen uptake improved, and the telomere length increased from 6178 pb, i.e. second lowest quartile, to 6408 pb, i.e. second highest quartile of the normal range, reflecting an increase in lifespan.
  • A 26 years old Stanford creative writing student with long standing and recurrent inflammatory disease of unknown cause with constitutional complaints, musculo-skeletal symptoms, long confinement to bed, recurrent diarrhea undergoes three microbiome exchange treatments, almost a year later she has resumed her studies without limitations and had almost forgotten that she ever had been handicapped before. 
  • A 29 years old business student from Indonesia, got involved in a robbery incident, and suffered cerebral trauma when pushed from his motorcycle, with two weeks in coma. Recovery after the hospital stay had not been complete, due to cognitive impairment, slowed speech, double vision, decreased performance, anxiety, depression and impaired self esteem with consequent increase in body weight and loss in former interests. Following six microbiome exchange treatments and six months later, he has resumed working out twice per week with his personal trainer, restored his social relations and former popularity. He feels confident enough now to apply for a job.
  • A 22 years old model from Columbia, suffering from recurrent abdominal pain, and constipation following abdominal surgery for malrotation in childhood, becomes completely asymptomatic two months following microbiome exchange treatments.

 

RESTAURATION OF A HEALTHY GUT MICROBIOME


 

GUT-HEART AXIS:  RESTAURATION OF THE MICROBIOME APPEARS TO HAVE ANTI-ARTERIOSCLEROTIC EFFECTS

REGENERATIVE MEDICINE PROGRAMS

 

  • We offer novel treatment programs in regenerative medicine at The Dolder Grand Health & Aesthetic Link practice, in cooperation with Double Check Swiss Academic Center Zurich and leading Swiss medical institutions, both private and University-associated
  • Stand out among your peers, come for measurable and lasting health benefits, fresh looks and vitality
  • Look and feel younger than your age
  • Increase wellbeing, prowess and physical magnetism
  • For hormonal renewal and lifespan extension (telomere length ↑)
  • For improved overall health and metabolism (blood lipids↓ & sugar ↓)
  • For prevention or treatment of difficult-to-treat ailments, accelerated aging, auto-immune disease, inflammatory disease, degenerative diseases of the nervous system, depression, anorexia nervosa, bulimia nervosa, diabetes, obesity, and heart disease (coronary artery disease, heart failure)

 

MICROBIOME-BASED THERAPIES

 

  • This program provides support for the application of microbiome-based regenerative therapy  in a controlled and safe setting. All accompanying state-of-the-art diagnostic and therapeutic measures including checkup examinations are provided by the Double Check Center in Zurich (www.doublecheck.ch). Basis of this program is a general health program, duration one to seven days.
  • Day 0:  Check-in at your hotel or clinic, first consultation, program set-up
  • Day 1: Somatic checkup (at Double Check)
  • Double Check examination, depending on the patient’s preferences and needs (Executive / Executive plus, Individual)
  • Comprehensive laboratory testing, toxicology screening
  • Biological age (as measured by telomere length)
  • Further diagnostics, imaging, endoscopy if needed and desired
  • Day 1-3: Choices of regenerative medicine therapies
  • Day 2-7: Choices of personal training and enhancement
  • Day 1-7: Final assessment  with PD Dr. R. Arendt, hand-out of medical report with recommendations and prescriptions

 

Our donors are the most active, enthusiastic and blissful young people

 

LATEST  RESULTS  FROM  MICROBIOME  RESEARCH

 

CONSULTATIONS

 

  • A Double Check Executive Checkup  
    Alternative: Executive Plus Checkup 
  • Additional laboratory (hormones, xenobiotic metals, toxins)
  • Genetic assessment  of life span (telomere length)
  • Micro RNA extracts
  •    8 I.M. injections for repair   
  •    12 I.M. injections for repair
  • Gut microbiome exchange
        for 3 treatments
        for 5 treatments
  • Face rejuvenation by skin microbiome exchange
        for 3 treatments
  • Vaginal rejuvenation by vaginal microbiome exchange
       for 3 treatments
  • Oral chelation (detox) therapy per week
  • Consultation with PD Dr. Rainer Arendt
      o internal medicine, cardiology
      o personal coaching, autohypnosis, EMDR, HT (per hour) 
  • Consultation with co-therapists
      o Personal coaching / training (per hour)
      o Mogalates posture and embodiment therapy (per hour) 
  • Optional: Consultation with specialists in all medical fields
  • Holistic and biological addiction treatment (per week)
  • Holistic and biological treatment of eating disorders (per week)

 

 

REGAINING  YOUTHFULNESS  IN  THE  LITERATURE

“Youth — nothing else worth having in the world…and I had youth, the transitory, the fugitive, now, completely and abundantly. Yet what was I going to do with it?
I wanted freedom, freedom to indulge in whatever caprice struck my fancy, freedom to search in the farthermost corners of the earth for the beautiful, the joyous and the romantic.”

Richard Halliburton, 
The Royal Road to Romance (1925)

 

 

 

 

 

 

 

 

 

 

 

 

 

For your individually tailored health and regeneration package contact us

 

 

 

Tuesday
Dec012015

THE HUMAN MICROBIOME 2016: the future in diagnostics and therapeutics

The Dolder Grand Health
Long Life & Vitality

PD Dr. Rainer Arendt
Internal Medicine & Cardiology FMH
Prevention & Regenerative Medicine


The future in diagnostics and therapeutics has arrived already today.

We look at a person's microbes and ensure the right balance is there and make adjustments if necessary to keep that person in optimal health.

Here we present 

 

  • An overview of the human microbiome project
  • Integrated omic analyses: including concomitant metagenomics, metatranscriptomics, metaproteomics, and metabolomics
  • Case studies: the microbiome and its role in inflammation, obesity, immunity, diabetes and cancer
  • Potential for microbiota-directed therapies
  • Skin microbiome - acne, eczema and wound healing
  • Oral microbiome
  • Impact of preterm birth prevention and management strategies on the vaginal microbiome
  • The lung microbiome and potential diagnostics and therapeutics
  • The microbiome-gut-brain axis and its impact on behaviour, addiction, and neurodegenerative diseases
  • Personalized nutrition and microbiome research
  • Impact of specific nutrients on the early life window
  • The development of next generation probiotics

 

The Human Microbiome has a well-documented and significant impact on human health and well-being. The advances in next generation sequencing technologies have aided scientific research in connecting an imbalanced microbiome (dysbiosis) to conditions as diverse as cancer, pulmonary, metabolic, inflammatory and mental/neurodegenerative disease.

Despite the recency of much of this research numerous applications are rapidly emerging. The strong evidence that gut microbiome transplantation/transfer (an individual biological therapy) is spectacularly efficacious in treating certain infectious or difficult-to-treat diseases and the percetion that the microbiome is uniquely manipulable is proving very exciting for researchers, physicians and patients alike.

Collaborations and research consortia are underway around the world surveying human microbiota at different body sites, characterising them, understanding their interactions with their host, their cause and effect role in diseases, and designing therapeutic or dietary interventions.

Whilst no on-the-shelf therapeutics exist yet, links between humans and bacteria are said to be on the cusp of a revolution in biological therapeutics. 

 

PD Dr. med. Rainer Arendt
FMH Cardiology, Internal Medicine
Regenerative Medicine 

SWISS  PREVENTION  CLINIC
Klausstrasse 10
CH-8008 ZURICH
T +41 43 336 7260
M +41 78 825 0803
F +41 43 336 7261

rainer.arendt@swisspreventionclinic.ch

www.swisspreventionclinic.ch
www.patientcircle.org

Saturday
Jul182015

"No More Dying. The Conquest Of Aging And The Extension Of Human Life" (Joel Kurtzman & Philip Gordon)

Fixing the ‘Problem’ of Aging: A Practical Scientific Approach to Life Extension in Good Health And Vitality

 

The Dolder Grand Health
Long Life & Vitality

PD Dr. Rainer Arendt
Internal Medicine & Cardiology FMH
Prevention & Regenerative Medicine


We offer gut microbiome exchange (transplantation) as novel opportunity for lifespan extension, prevention and treatment of various and so far difficult to treat ailments (auto-immune diseases, multiple sclerosis, vision loss due to uveitis, metabolic disorders, neuro-psychiatric diseases, Parkinson and addictions, cardiovascular disease, endocrine disorders and infertility, cancer).

 

It is the rich array of microbiota in our intestines that makes us the human beings we are, preserves our health, and determines our lifespan.

 

"Just as a vintage car can be kept in good condition indefinitely with periodic preventative maintenance, so there is no reason why, in principle, the same can’t be true of the human body."

 

As it appears, we have come closer to “solve aging” and get people to live, healthily, up to the apparent maximum of the human lifespan of about 120 years (the longest known/confirmed lifespan was 122 years) or even longer. Already today, we are able to restore vitality and extend lifespan by restoring the epigenetic control of our genome (it is epigenetics, the environment we carry with us in our gut that determines aging, not genetics, we do not need to change genes, we just change the gut bacteria that control our genes), by replenishing / restoring the youthful richness of our gut microbiome.

Our microbiomes contain well over 1 million genes, compared with our 23,000 genes. Furthermore, the commensal microbiome accounts for 90% of the cells in our bodies. Among other functions, these gastrointestinal symbiotes help form and maintain our immune system and aid in digestion, so their health is critical to our health. The understanding of how microbiota contribute to our mental and medical well-being is rapidly advancing.

 

A modern version of the age old dream of tapping the fountain of youth – is emblematic of the current enthusiasm sweeping the research community, to reverse engineer the biology that controls lifespan and “devise interventions that enable people to lead longer and healthier lives“.

Aubrey de Grey is enjoying the new buzz about defeating ageing. For more than a decade, he has been on a crusade to inspire the world to embark on a scientific quest to eliminate aging and extend healthy lifespan (he is on the Palo Alto Longevity Prize board). It is a difficult job because he considers the world to be in a “pro-aging trance”, happy to accept that aging is unavoidable, when the reality is that it’s simply a “medical problem” that science can solve.

His claims about the possibilities, and some unconventional and unproven ideas about the science behind aging, have long made de Grey unpopular with mainstream academics studying aging. But the appearance of Calico and others suggests the world might be coming around to his side, he says. “There is an increasing number of people realising that the concept of anti-aging medicine that actually works is going to be the biggest industry that ever existed by some huge margin and that it just might be foreseeable.”

De Grey isn’t the only one who sees a new flowering of anti-aging research (mostly been aimed at extending “healthspan”, the years in which you are free of frailty or disease, rather than lifespan, although an obvious effect is that it would also be extended, healthy people after all live longer). “Radical life extension isn’t consigned to the realm of cranks and science fiction writers any more,” says David Masci, a researcher at the Pew Research Centre, who recently wrote a report on the topic looking at the scientific and ethical dimensions of radical life extension. “Serious people are doing research in this area and serious thinkers are thinking about this.”

Life expectancy has risen in developed countries from about 47 in 1900 to about 80 today, largely due to advances in curing childhood diseases. But those longer lives come with their share of misery. Age-related chronic diseases such as heart disease, cancer, stroke and Alzheimer’s are more prevalent than ever.

“If a consequence of increasing health is that life is extended, that’s a good thing, but the most important part is keeping people healthy as long as possible,” says Kevin Lee, a director of the Ellison Medical Foundation, founded in 1997 by tech billionaire Larry Ellison, and which has been the field’s largest private funder, spending $45m annually. (The Paul F Glenn Foundation for Medical Research is another.) Whereas much biomedical research concentrates on trying to cure individual diseases, say cancer, scientists in this small field hunt something larger. They investigate the details of the aging process with a view to finding ways to prevent it at its root, thereby fending off the whole slew of diseases that come along with aging.

 

The standard medical approach – curing one disease at a time – only makes that worse, says Jay Olshansky, a sociologist at the University of Chicago School of Public Health who runs a project called the Longevity Dividend Initiative, which makes the case for funding aging research to increase healthspan on health and economic grounds. “I would like to see a cure for heart disease or cancer,” he says. “But it would lead to a dramatic escalation in the prevalence of Alzheimer’s disease.”

 

By tackling aging at the root that could be dealt with as one, reducing frailty and disability by lowering all age-related disease risks simultaneously, says Olshansky. Evidence is now building that this bolder, age-delaying approach could work. “We have really turned a corner,” says Brian Kennedy, director of the Buck Institute for Research on Aging, adding that five years ago the scientific consensus was that aging research was interesting but unlikely to lead to anything practical. “We’re now at the point where it’s easy to extend the lifespan…,” says David Sinclair, a researcher based at Harvard.

 

One of the novel approaches being tested is using gut microbiota from the young to reinvigorate the old, to help them live longer.

This appears to work by simulating the internal chemical properties of a young body. In The Selfish Gene, Richard Dawkins describes an approach to life-extension that involves "fooling genes" into thinking the body is young.  Dawkins attributes inspiration for this idea to Peter Medawar. The basic idea is that our bodies are composed of genes that activate throughout our lifetimes, some when we are young and others when we are older. Presumably, these genes are activated by environmental factors (inside our gut), and the changes caused by these genes activating can be lethal. It is a statistical certainty that we possess more lethal genes that activate in later life than in early life. Therefore, to extend life, we should be able to prevent these genes from switching on, and we should be able to do so by identifying changes in the internal chemical environment of a body that take place during aging... .

The aim is to begin clinical studies of aging but these are difficult because of the length of our lives, though there are ways around this such as testing the length of telomeres in blood cells, the telomeres of young cells are longer than the telomeres of middle-aged cells, which, in turn are longer than the telomeres of old cells, and looking for signs of improvements in other conditions at the same time. Actually, the gut microbiome exchange appears to delay aging in every part of your body. As to when you might begin treatment, we suggest you could start treatment sometime between the age of 35 and 70 “because it keeps you healthy at least 10 years longer”.

 

 

 

“A lot of people spend their lasts decade of their lives in pain and misery combating disease,” says Craig Venter, San Diego based pioneering biologist and billionaire entrepreneur, …“I think it is possible to begin to do more about that than we are doing.” “I am not sure our brains and our psychologies are ready for immortality,” he says. “[But] if I can count on living to 100 without major debilitating diseases I would accept that Faustian bargain right now.”

“We’re tackling aging, one of life’s greatest mysteries,” we have a desire to make each day of our lives count, to make the most of life, to live longer and healthier.

 

 

 

PD Dr. med. Rainer Arendt
FMH Cardiology, Internal Medicine
Regenerative Medicine 

SWISS  PREVENTION  CLINIC
Klausstrasse 10
CH-8008 ZURICH
T +41 43 336 7260
M +41 78 825 0803
F +41 43 336 7261

rainer.arendt@swisspreventionclinic.ch

www.swisspreventionclinic.ch
www.patientcircle.org